RESEARCH

RESEARCH

PhD (2016 - 2021)

Lidya recently completed her PhD at Ontario Tech University. She was a member of the Desaulniers Lab which specializes in the synthesis of modified nucleic acids for several applications. Lidya's research involved the synthesis of short interfering RNAs (siRNAs). These biomolecules are able to reduce the expression of a target protein through the native RNA interference (RNAi) pathway. Lidya's dissertation focused on the development of safe and effective delivery systems for modified siRNAs and resulted in three primary publications, a review article and a preparation manuscript to be submitted this year. 

Honours Thesis (2015 - 2016)

Lidya completed an Undergraduate Honours Thesis at Ontario Tech University, co-supervised by Prof. Jean-Paul Desaulniers and Prof. Sean Forrester. This interdisciplinary project involved the chemical synthesis of γ-Amino-β-hydroxybutyric acid (GABOB) derivatives to target GABAA receptors in the parasitic worm Haemonchus contortus.

PUBLICATIONS

Sarah Habibi and Lidya Salim


Static vs. dynamic methods of delivery for science communication: A critical analysis of user engagement with science on social media. PLoS ONE, 2021.

Lidya Salim, Eva Goss and J.P. Desaulniers

 

Synthesis and Evaluation of Modified siRNA Molecules Containing a Novel Glucose Derivatives. RSC Advances, 2021.

Lidya Salim and J.P. Desaulniers

 

To Conjugate or to Package? A Look at Targeted siRNA Delivery Through Folate Receptors. Nucleic Acid Therapeutics, 2021.

Andrew Varley, Matt Hammill, Lidya Salim, and J.P. Desaulniers


Effects of Chemical Modifications on siRNA Strand Selection in Mammalian Cells. Nucleic Acid Therapeutics, 2020.

Lidya Salim, Golam Islam, and J.P. Desaulniers

Targeted delivery and enhanced gene-silencing activity of centrally modified folic acid–siRNA conjugates. Nucleic Acids Research, 2020.

Lidya Salim, Chris McKim, and J.P. Desaulniers

Effective carrier-free gene-silencing activity of cholesterol-modified siRNAs. RSC Advances, 2018.

Sean Forrester, Joshua Foster, Sebastien Robert, Lidya Salim, and J.P. Desaulniers

Efficient synthesis of the GABAA receptor agonist trans-4-aminocrotonic acid (TACA). Bioorg. Med. Chem. Lett, 2017.

PRESENTATIONS

Virtual Poster Presentation: Targeted delivery and enhanced gene-silencing activity of folic acid-siRNA conjugates in cancer cells.

RNA 2020. Virtual Conference, May 2020

Virtual Flash Talk: Targeting the Messenger: Silencing Gene Expression in Cancer Cells.

Leaders Overcoming Gender Inequality in Chemistry (LOGIC) 2020. Virtual Conference, May 2020

Poster Presentation: Centrally-modified folic acid-siRNAs exhibit enhanced gene-silencing
activity and efficient receptor-mediated uptake in cancer cells.

Oligonucleotide Therapeutics Society Annual Meeting, Munich, Germany, October 2019

Poster Presentation: Targeted delivery of short-interfering RNAs (siRNAs) to cancer cells via folate receptors.

102nd Canadian Chemistry Conference and Exhibition (CCCE), Quebec City, Canada, June 2019


Oral Presentation: Targeted delivery and enhanced gene-silencing activity of centrally-modified folic acid-siRNA conjugates.

10th-Annual Graduate Student Research Conference, Oshawa, Canada, May 2019


Poster Presentation: The Synthesis and Biological Activity of Folic Acid-Modified siRNAs.

101st Canadian Chemistry Conference and Exhibition (CSC 2018), Edmonton, Canada, June 2018


Oral Presentation: Targeted delivery of short-interfering RNAs (siRNAs) to cancer cells via folate receptors.

2nd-Annual Ontario Tech-KIT Mini-Symposium in Chemistry, Oshawa, Canada, September 2018

Oral Presentation: Synthesis of siRNAs with Central-Region Folic Acid Modifications to Assess Gene Silencing Efficacy.

1st-Annual Ontario Tech-KIT Mini-Symposium in Chemistry, Oshawa, Canada, September 2017