PhD (2016 - 2021)
Lidya recently completed her PhD at Ontario Tech University. She was a member of the Desaulniers Lab which specializes in the synthesis of modified nucleic acids for several applications. Lidya's research involved the synthesis of short interfering RNAs (siRNAs). These biomolecules are able to reduce the expression of a target protein through the native RNA interference (RNAi) pathway. Lidya's dissertation focused on the development of safe and effective delivery systems for modified siRNAs and resulted in three primary publications, a review article and a preparation manuscript to be submitted this year.
Honours Thesis (2015 - 2016)
Lidya completed an Undergraduate Honours Thesis at Ontario Tech University, co-supervised by Prof. Jean-Paul Desaulniers and Prof. Sean Forrester. This interdisciplinary project involved the chemical synthesis of γ-Amino-β-hydroxybutyric acid (GABOB) derivatives to target GABAA receptors in the parasitic worm Haemonchus contortus.
Sean Forrester, Joshua Foster, Sebastien Robert, Lidya Salim, and J.P. Desaulniers
Efficient synthesis of the GABAA receptor agonist trans-4-aminocrotonic acid (TACA). Bioorg. Med. Chem. Lett, 2017.
Virtual Poster Presentation: Targeted delivery and enhanced gene-silencing activity of folic acid-siRNA conjugates in cancer cells.
RNA 2020. Virtual Conference, May 2020
Virtual Flash Talk: Targeting the Messenger: Silencing Gene Expression in Cancer Cells.
Leaders Overcoming Gender Inequality in Chemistry (LOGIC) 2020. Virtual Conference, May 2020
Poster Presentation: Centrally-modified folic acid-siRNAs exhibit enhanced gene-silencing
activity and efficient receptor-mediated uptake in cancer cells.
Poster Presentation: Targeted delivery of short-interfering RNAs (siRNAs) to cancer cells via folate receptors.
102nd Canadian Chemistry Conference and Exhibition (CCCE), Quebec City, Canada, June 2019
Oral Presentation: Targeted delivery and enhanced gene-silencing activity of centrally-modified folic acid-siRNA conjugates.
10th-Annual Graduate Student Research Conference, Oshawa, Canada, May 2019
Poster Presentation: The Synthesis and Biological Activity of Folic Acid-Modified siRNAs.
101st Canadian Chemistry Conference and Exhibition (CSC 2018), Edmonton, Canada, June 2018
Oral Presentation: Targeted delivery of short-interfering RNAs (siRNAs) to cancer cells via folate receptors.
2nd-Annual Ontario Tech-KIT Mini-Symposium in Chemistry, Oshawa, Canada, September 2018
Oral Presentation: Synthesis of siRNAs with Central-Region Folic Acid Modifications to Assess Gene Silencing Efficacy.
1st-Annual Ontario Tech-KIT Mini-Symposium in Chemistry, Oshawa, Canada, September 2017